Hangzhou AllTest Biotech CO.,LTD 

      Your Reliable Rapid Test Partner!

Home
Products
About Us
Factory Tour
Quality Control
Contact Us
Request A Quote
News
Home News

Mitochondrial DNA is Early Marker of Severe COVID-19 Illness

I'm Online Chat Now
China Hangzhou AllTest Biotech CO.,LTD certification
China Hangzhou AllTest Biotech CO.,LTD certification
I like the products and service provided by AllTest. They really take our interest into consideration.

—— Mr John Smith England

My oldest daughter actually has Lyme disease. She spent almost 1 year in a wheelchair because of Lyme. She is doing very well now. I used 2 of the samples. 1 to test my Lyme diagnosed daughter and 1 to test my daughter who does not have Lyme. Your tests worked well. My daughter with Lyme tested positive and the one who does not tested negative.

—— Ms Sheila

Whenever I have the requests,AllTest always give me the satisfied reply at the first time.

—— Mrs Julie Tschetter Belgium

As the old customer of AllTest since 2009, we should thank the great work have been done by AllTest to support us gain more market share and profit

—— Mr Robin Seifert Germany

Company News
Mitochondrial DNA is Early Marker of Severe COVID-19 Illness
Latest company news about Mitochondrial DNA is Early Marker of Severe COVID-19 Illness

Mitochondrial DNA (MT-DNA) levels assessed within a day of patients’ hospitalization for COVID-19 were highly elevated in those who ultimately died, required intensive care, intubation, or vasopressor or renal replacement therapy in comparison to those without these complications. After further validation, this testing, performed in about an hour using standard reverse transcription-polymerase chain reaction (rt-PCR) but without a DNA purification step, could give doctors a tool to know better when to implement treatments such as monoclonal antibodies.

 

Viral infections can trigger cellular necrosis, which releases MT-DNA and other MT-damage associated molecular patterns known to cause acute lung injury and systemic inflammation. With these pathologies found in COVID-19, the authors questioned whether elevated levels of circulating MT-DNA might be a risk factor for severe disease.

 

The blood samples of 97 patients with laboratory-confirmed SARS-CoV-2 infection admitted to Barnes-Jewish Hospital in St. Louis underwent two rounds of centrifugation to generate platelet poor plasma. The investigators then performed rt-PCR using a BioRad CFX-Connect instrument to measure MT-DNA levels.

 

The researchers found that MT-DNA levels were about 10-times higher in those who developed acute respiratory failure or eventually died. After multivariate analysis adjusting for age, sex, and comorbidities, MT-DNA remained an independent risk factor for mortality (2.24 adjusted odds ratio (OR); 1.28–4.16 95% confidence interval (CI); p value 0.015), intensive care admission (3.97 adjusted OR; 1.83–10.34 CI; p value 0.002), and intubation (8.48 adjusted OR; 3.48–27.33 CI; <0.0001 p value).

 

In comparison to other markers of inflammation typically measured in COVID-19 patients, including C-reactive protein, ferritin, lactase dehydrogenase, and D-dimer, MT-DNA levels yielded similar or improved area under the receiver operator characteristic (AUROC) for key outcomes (mortality and intensive care, similar AUROC of 0.68 and 0.75, respectively; intubation, superior AUROC at 0.86%).

Pub Time : 2021-08-03 10:01:40 >> News list
Contact Details
Hangzhou AllTest Biotech CO.,LTD

Contact Person: Mrs. Selina

Tel: +86 13989889852

Fax: 86-571-56267856

Send your inquiry directly to us