Serology assays to detect circulating antibodies directed against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gained popularity for primarily two reasons. They were originally not regulated under the emergency use authorization (EUA) and could be easily implemented. Furthermore, specimens for serologic testing are easily obtained via phlebotomy and do not require a specialized collection device.
The concept of presumptive immunity is commonly used for infectious diseases with effective vaccines and assumes that individuals with antibodies are protected from the infection. The long-standing scientific rationale behind presumptive immunity is antibody-mediated viral neutralization – antibodies produced by the host lymphocytes bind to viral particles and inhibit viral entry into host cells, thereby preventing infection.
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