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Hangzhou AllTest Biotech CO.,LTD 

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I like the products and service provided by AllTest. They really take our interest into consideration.

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My oldest daughter actually has Lyme disease. She spent almost 1 year in a wheelchair because of Lyme. She is doing very well now. I used 2 of the samples. 1 to test my Lyme diagnosed daughter and 1 to test my daughter who does not have Lyme. Your tests worked well. My daughter with Lyme tested positive and the one who does not tested negative.

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EBV VCA IgG Rapid Test Cassette (Whole Blood/Serum/Plasma)

Product Details:

Place of Origin:CHINA
Brand Name:AllTest
Certification:CE
Model Number:IECG-402

Payment & Shipping Terms:

Minimum Order Quantity:500
Packaging Details:20T/Kit
Supply Ability:100 Million a year
Detailed Product Description
Format: Cassette Specimen: Swab
Kit Size: 20T/Kit Storage: 2-30℃
Shelf Time: 24 Months Certificate: CE

A rapid test for the qualitative detection of Strep B antigen CE certified

 

 

Applications: 

 

The EBV VCA IgG Rapid Test Cassette (Whole Blood/Serum/Plasma) is a rapid chromatographic immunoassay for the qualitative detection of IgG antibody to Viral Capsid Antigen (VCA) of Epstein-Barr virus in human whole blood, serum, or plasma.

 

 

Description: 

 

Epstein-Barr Virus (EBV) is a ubiquitous human virus which causes infectious mononucleosis (IM), a self- limiting lymphoproliferative disease 1 . By adulthood virtually everyone has been infected with and has developed immunity to the virus. In underdeveloped countries, seroconversion to the virus takes place in early childhood and is usually asymptomatic 2 . In more affluent countries, primary EBV infections are often delayed until adolescence or later, and manifest as IM in about 50% of this age group 3-5 . Following seroconversion, whether symptomatic or not, EBV establishes a chronic, latent infection in B lymphocytes which probably lasts for life 6 . EBV replicates in oropharyngeal epithelial cells and is present in the saliva of most patients with IM 7 . In addition, 10-20% of healthy persons who are EBV antibody positive shed the virus in their oral secretions 6-8 . Reactivation of the latent viral carrier state, as evidenced by increased rates of virus shedding, is enhanced by immunosuppression, pregnancy, malnutrition, or disease 8,9 . Chronic EBV infections, whether latent or active, are rarely associated with disease. However, EBV has been implicated at least as a contributing factor in the etiology of nasopharyngeal carcinoma, Burkitt’s lymphoma, and lymphomas in immunodeficient patients 4,8 .
The Paul-Bunnell-Davidsohn test for heterophile antibody is highly specific for IM 10 . However, 10-15% of adults and higher percentages of children and infants with primary EBV infections do not develop heterophile antibodies 11 . There is a need for EBV-specific serological tests to differentiate primary EBV infections that are heterophile negative, from mononucleosis-like illnesses caused by other agents such as cytomegalovirus, adenovirus, and Toxoplasma gondii 4 . Antibody titers to specific EBV antigens correlate with different stages of IM 4,10-12 . Both IgM and IgG antibodies to the viral capsid antigen (VCA) peak three to four weeks after primary EBV infection. Anti-VCA IgM antibodies decline rapidly and are usually undetectable after 12 weeks. Anti-VCA IgG antibody titers decline slowly after peaking but last indefinitely. Antibodies to EBV nuclear antigen (EBNA) develop from one month to six months after infection and, like anti-VCA antibodies, persist indefinitely 11,12 . Antibodies to EBNA indicate that the infection was not recent 11 .
EBV early antigens (EA) consist of two components; diffuse (D), and restricted (R). The terms D and R reflect the different patterns of immunofluorescent staining exhibited by the two components 13,14 . Antibodies to EA appear transiently for up to three months during the acute phase of IM in 85% of patients 15,16 . The antibody response to EA in IM patients is usually to the D component, whereas silent seroconversion to EBV in children produces antibodies to the R component 5,11 . A definitive diagnosis of primary EBV infection can be made with 95% of acute phase sera based on the detection of antibodies to VCA, EBNA, and EA 12 .
The EBV VCA IgG Rapid Test Cassette (Whole Blood/Serum/Plasma) is a rapid test that utilizes a combination of EBV VCA antigen coated colored particles for the detection of VCA IgG antibody to Epstein-Barr virus in human whole blood, serum, or plasma.

 

 

How to use? 

 

Allow the test cassette, specimen, buffer and/or controls to reach room temperature (15-30°C) prior to testing.
1. Bring the pouch to room temperature before opening it. Remove the test cassette from the sealed pouch and use it within 1 hour.
2. Place the cassette on a clean and level surface.
To use a dropper: Hold the dropper vertically, draw the specimen about 1cm above the upper end of the nozzle as shown in illustration, transfer 1 drop of the serum/plasma (approximately 10μl) or 2 drops of the whole blood (approximately 20μl) to the specimen well (S) of the test cassette, then add 2 drops of buffer (approximately 80μl) and start the timer. See the illustration below.
To use a micropipette: Pipette and dispense 10μl of serum/plasma or 20μl of whole blood to the specimen well (S) of the test cassette, then add 2 drops of buffer (approximately 80μl) and start the timer. See the illustration below.
Wait for the colored line(s) to appear. Read result at 15 minutes. Do not interpret the result after 20 minutes.
Note: It is suggested not to use the buffer beyond 6 months after opening the vial.

 

 

 

 
   

INTERPRETATION OF RESULTS

 

(Please refer to the illustration above)

 

POSITIVE: * Two distinct colored lines appear. One colored line should be in the control region (C) and another colored line should be in the test region (T).
*NOTE: The intensity of the color in the test line region (T) will vary depending on the concentration of EBV VCA IgG present in the specimen. Therefore, any shade of color in the test region should be considered positive.
NEGATIVE: One colored line appears in the control region (C). No apparent colored line appears in the test region (T).
INVALID: Control line fails to appear. Insufficient specimen volume or incorrect procedural techniques are the most likely reasons for control line failure. Review the procedure and repeat the test with a new test cassette. If the problem persists, discontinue using the test kit immediately and contact your local distributor.

Contact Details
Hangzhou AllTest Biotech CO.,LTD

Tel:86-571-56267891

Fax:86-571-56267856

Contact Person: Mrs. Selina

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