CIT Rapid Test Dipstick(Urine), Citalopram Test Kit. Detection Of Desmethylcitalopram

CIT Rapid Test Dipstick (Urine), Citalopram Test Kit. detection of Desmethylcitalopram

Product Name:	CIT Rapid Test Dipstick(Urine), Citalopram Test Kit. Detection Of Desmethylcitalopram
Brand:	AllTest
Format:	Cassette
Certificate:	CE
Pack:	50T
Shelf Life:	2 Years
Specificity:	95.50%
Cut-Off:	500 Ng/mL
CAT NO.:	DCIT-111/101
Principle:	Chromatographic Immunoassay
Specimen:	Urine
Reading Time:	5 Minutes
Storage Temperature:	2-30°C
Sensitivity:	93.30%
Accuracy:	94.80%
PRODUCT FEATURES:	High Accuracy

Application

The CIT Rapid Test Dipstick (Urine) is a rapid chromatographic immunoassay for the detection of Desmethylcitalopram in urine at a cut-off concentration of 500ng/ml. This test will detect other related compounds, please refer to the Analytical Specificity table in this package insert.

This assay provides only a qualitative, preliminary analytical test result. A more specific alternate chemical method must be used in order to obtain a confirmed analytical result. Gas chromatography/mass spectrometry (GC/MS) is the preferred confirmatory method. Clinical consideration and professional judgment should be applied to any drug of abuse test result, particularly when preliminary positive results are used.

SUMMARY

Citalopram, an antidepressant of the selective serotonin reuptake inhibitor (SSRI) type, is only available as a racemic drug. Its metabolism occurs, partially, by N-demethylation to demethylcitalopram (DCIT) and didemethylcitalopram (DDCIT), but also by deamination to a propionic acid derivative (CIT-PROP) and by N-oxidation to CIT-N-oxide (NO-CIT) [1]. CIT has equal affinity for 5-HTT and dopamine transporters [2] . Studies have shown that compared with healthy subjects, the binding potential of thalamus and brainstem binding area in patients with depression who take 20-60 mg citalopram every day is reduced by 50% [3] .

It is supplied as the free base in 20 mg tablets oral administration; daily oral dose for adults usually range from 20-60 mg. The common adverse reactions were nausea, dry mouth and drowsiness. The rare adverse reactions were agitation, income and anxiety. The oral bioavailability of citalopram is about 80%.15% of citalopram is excreted by kidney, and 12%-23% of citalopram in daily dose is excreted in original form from urine.

PRINCIPLE

The CIT Rapid Test Dipstick (Urine) is an immunoassay based on the principle of competitive binding. Drugs which may be present in the urine specimen compete against the drug conjugate for binding sites on the antibody. During testing, a urine specimen migrates upward by capillary action. Desmethylcitalopram, if present in the urine specimen below the cut-off level, will not saturate the binding sites of the antibody in the test. The antibody coated particles will then be captured by immobilized Citalopram-protein conjugate and a visible colored line will show up in the test line region. The colored line will not form in the test line region if the Desmethylcitalopram level exceeds the cut-off level, because it will saturate all the binding sites of anti-citalopram antibody.

A drug-positive urine specimen will not generate a colored line in the test line region because of drug competition, while a drug-negative urine specimen or a specimen containing a drug concentration less than the cut-off will generate a line in the test line region. To serve as a procedural control, a colored line will always appear at the control line region indicating that proper volume of specimen has been added and membrane wicking has occurred.

DIRECTIONS FOR USE

Allow the test, urine specimen, and/or controls to reach room temperature (15-30°C) prior to testing.

1. Bring the pouch to room temperature before opening it. Remove the test card from the sealed pouch and use it within one hour.

2. With the arrow pointing toward the urine specimen, immerse the test dipstick vertically in the urine specimen in such a way that urine does not cross MAX line on the test Dipstick for 10-15 seconds. See the illustration below.

3. Place the Test Dipstick on a non-absorbent flat surface, start the timer and wait for the colored line(s) to appear. Read results at 5 minutes. Do not interpret the result after 10 minutes.

INTERPRETATION OF RESULTS

(Please refer to the illustration above)

NEGATIVE:* Two colored lines appear. One colored line should be in the control line region (C), and another apparent colored line should be in the test line region (T). This negative result indicates that the Desmethylcitalopram concentration is below the detectable cut-off level.

*NOTE: The shade of color in the test line region (T) may vary, but it should be considered negative whenever there is even a faint colored line.

POSITIVE: One colored line appears in the control line region (C). No line appears in the test line region (T). This positive result indicates that the Desmethylcitalopram concentration exceeds the detectable cut-off level.

INVALID: Control line fails to appear. Insufficient specimen volume or incorrect procedural techniques are the most likely reasons for control line failure. Review the procedure and repeat the test with a new test. If the problem persists, discontinue using the test kit immediately and contact your local distributor.

Tag:

Place of Origin:	China
Brand Name:	ALLTEST
Certification:	CE
Model Number:	DCIT-101/111

Minimum Order Quantity:	N/A
Price:	negotiation
Packaging Details:	50T
Delivery Time:	2-4 Weeks
Supply Ability:	10 M tests/month

	Hangzhou AllTest Biotech CO.,LTD
	#383, Qiaoxin Road, Xiasha Street, Qiantang Disctrict, Hangzhou, Zhejiang, P.R.China
	86-571-56267891
	selina.wu@alltests.com.cn

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